La Ronge RCMP are investigating a fatal rollover north of the community.
Police say the single-vehicle crash happened around 5:30 Friday morning on Highway 102.
One passenger, a 31-year-old woman from La Ronge, was declared dead at the scene.
The driver and two other occupants were taken to hospital with serious injuries.
RCMP say a collision reconstructionist is assisting in the investigation.
Highway 102 remains closed, and drivers are being asked to avoid the area and check the Highway Hotline for updates.