Shellbrook RCMP arrested three men on the Ahtahkakoop Cree Nation in the early morning hours of Tuesday.
Items seized during a search warrant of a local residence include a firearm, two pellet guns, multiple rounds of ammunition, an undefined amount of cocaine and drug paraphernalia.
Shellbrook police were assisted by emergency response teams from Saskatchewan and Alberta and the Prince Albert Integrated Street Enforcement Team.
Investigation is ongoing.