A 15-year study into premature death finds the rate is more than twice as high in the First Nations community.
First Nations adults between the ages of 25 and 74 are more than twice as likely to die from avoidable causes compared to non-aboriginal adults.
The results were compiled by Statistics Canada using census data from 1991 to 2006.
The rate for men was twice as high while the rate for women was two and a half times higher.
Avoidable deaths refer to deaths that could have been prevented through prevention, screening and timely health care.
They include things like pneumonia, tuberculosis, diabetes and drug or alcohol abuse.
First Nations adults were more than five times more likely to die from alcohol, drug use, and injuries than non-aboriginals.
The study also found that education and poverty played a major role in the high premature death rate.
It found the rates could be reduced by 47 per cent for aboriginal men and 32 per cent for aboriginal women if economic and education factors were the same for First Nations and non-aboriginal adults.